About CMR

At Center for Magnetic Resonance we conduct research and teaching within the field of Magnetic Resonance Imaging and Spectroscopy.

Magnetic Resonance is a powerful technique providing detailed information about the structure and dynamics of molecules (Nuclear Magnetic Resonance) or high-resolution anatomical and functional images (Magnetic Resonance Imaging). For instance, it can be used to examine the human body's function, metabolism and structure.

Nuclear Magnetic Resonance and Magnetic Resonance Imaging play crucial roles in numerous fields of science ranging from physics and chemistry to biology and medicine. We work with methods, hardware and applications in order to enable new possibilities in these fields. 

We rely on close collaborations with hospitals in Denmark and abroad. Several of our scientists are employed in shared positions between Center for Magnetic Resonance at DTU and Copenhagen University Hospital Hvidovre. And we carry out our research with colleagues from all national and many international MR science centers.

We work with Magnetic Resonance from different angles, most notably:

Hyperpolarization 

The magnetic resonance signal can be enhanced thousand-fold through hyperpolarization to overcome inherent sensitivity challenges. Hyperpolarization is obtained by the method ‘dissolution Dynamic Nuclear Polarization’, invented by the head of our research group, and is an activated state that decays in minutes. We study the basic physics and instrumentation behind hyperpolarization, develop coils and pulse sequences that allow optimal acquisition strategies, and we use hyperpolarization to gain further understanding of chemical and biochemical reactions. In living systems, from cell to man, this provides a tool to quantifying metabolic pathways and their alterations. One of the most compelling applications of hyperpolarization is in medical imaging. Hyperpolarized Metabolic MR has the potential to revolutionize diagnostic radiology by opening a window into organ and tissue metabolism at the cellular level in real-time and non-invasively.

MRI Acquisition Methodology

We develop acquisition technologies to improve MR scanning, e.g. with respect to speed, robustness, sensitivity or specificity. The methods range from fundamental physics to advanced data processing techniques needed to extract important physiological parameters from the measurements. The targets of the development include imaging, spectroscopy, and multi-modal acquisition. We develop new methods and hardware with the aim of achieving new valuable knowledge and treatments through MR. 

Neurophysics

We conduct methodological research on the modeling of biophysics of transcranial brain stimulation and on combined neurostimulation-neuroimaging approaches. We advance non-invasive transcranial brain stimulation (NTBS) methods as a means to modulate and shape brain activity. NTBS uses electric currents that are focally induced in superficial brain areas. We develop and apply biophysical models to reveal and optimize the current flow patterns in the brain and to estimate their impact on neural activity. The computational modeling work is complemented by applying neuroimaging approaches such as functional MRI (fMRI) and electroencephalography (EEG) to better characterize the impact of neurostimulation on brain activity. We are interested in human sensorimotor integration and motor control, which sets the neuroscientific scene in which we employ and test the NTBS methods.

High-Field MRI

Ultra-high field (7 tesla) MR allows new insights into the relationship between structure and function of the human body in health and diseas. However, it poses a series of technical challenges in order to reach the full potential. The improved signal-to-noise at 7 T allows submillimeter structural and functional image resolution, but a good compensation of subject motion is required to avoid image degradation. We work on fast image readout approaches and navigator-based correction methods to reduce the effects from motion and the increased physiological noise experienced at high field strength. We work on new transmit concepts to allow highly improved RF distributions in the human body, and thereby deliver superior image quality at safe SAR levels. Furthermore, we work on advanced shim and dephasing techniques to make novel zoom imaging methods and exclude unwanted tissue such as fat.

http://www.cmr.elektro.dtu.dk/about-cmr
18 NOVEMBER 2017